A novel study we contributed to provides the first detailed analysis of 3D chromatin organisation changes during the development of endothelium, and how they correlate with gene expression regulations. The study also compares these dynamics with those we previously reported for cardiomyogenesis; here are the highlights:

• In endothelial differentiation, compartment transitions regulate gene expression
• New TAD boundaries and chromatin loop anchors coordinate endothelial activation
• Frequent, growing chromatin loops accompany essential endothelial gene expression
• Cardiomyocytes evidence a markedly different topology versus endothelial cells

This work was led by two talented postdoc in the Murry and Noble laboratories at the University of Washington, Katie Mitzelfelt and Kris Alavattam, and was published on the ISSCR journal Stem Cell Report: 
https://www.cell.com/stem-cell-reports/fulltext/S2213-6711(22)00536-7

We are honoured to be among the FEBS Excellence Awardees class of '22!

FEBS launched a prestigious new programme in 2021 aimed at supporting highly competitive research in molecular life sciences: the FEBS Excellence Awards. The FEBS Excellence Awards provide €100,000 funding over three years to early-career group leaders working in a FEBS country to purchase laboratory equipment and consumables.

We are extremely grateful to FEBS for the support and we are eager to put these funds to good use to support our project entitled: "Chromatin Topology Dysregulation in Cardiac Cohesinopathies"

We are particularly proud to be the first group receiving this award in Italy, and we would be more than happy to help any perspective applicant in preparing their application. The call for applications for FEBS Excellence Awards in 2023 is expected to open in April 2023. The closing date will be 1 July 2023.

More info and full list of awardees on the FEBS website:
​https://www.febs.org/news/febs-excellence-awardees-2022/