Paper sheds lights on chromatin topology dynamics during endothelial vs. cardiac differentiation

A novel study we contributed to provides the first detailed analysis of 3D chromatin organisation changes during the development of endothelium, and how they correlate with gene expression regulations. The study also compares these dynamics with those we previously reported for cardiomyogenesis; here are the highlights:

• In endothelial differentiation, compartment transitions regulate gene expression
• New TAD boundaries and chromatin loop anchors coordinate endothelial activation
• Frequent, growing chromatin loops accompany essential endothelial gene expression
• Cardiomyocytes evidence a markedly different topology versus endothelial cells

This work was led by two talented postdoc in the Murry and Noble laboratories at the University of Washington, Katie Mitzelfelt and Kris Alavattam, and was published on the ISSCR journal Stem Cell Report: 
https://www.cell.com/stem-cell-reports/fulltext/S2213-6711(22)00536-7