Primary Research
*: co-first; #: co-senior; @: correspondence; bold text: PI/lab authors; underlined text: primary publications from the PI/lab
Privately archived full texts are provided by the author for personal use only; use the links to the publishers for all other pourposes
*: co-first; #: co-senior; @: correspondence; bold text: PI/lab authors; underlined text: primary publications from the PI/lab
Privately archived full texts are provided by the author for personal use only; use the links to the publishers for all other pourposes
Faculty
Marchiano S, Nakamura K, Reinecke H, Neidig L, Lai M, Kadota S, Perbellini F, Yang X, ... [15 authors], Kattman S, Thies RS, Sniadecki N, MacLellan WR, Bertero A #, Murry CE #@ (2023). Gene editing to prevent ventricular arrhythmias associated with cardiomyocyte cell therapy. Cell Stem Cell 30, 396-414
Ong LP *@, Bargehr J *, Knight-Schrijver VR, Lee J, Colzani M, Bayraktar S, Bernard WG, Marchiano S, Bertero A, Murry CE, Gambardella L #, Sinha S #@ (2023). Epicardially secreted fibronectin drives cardiomyocyte maturation in 3D-engineered heart tissues. Stem Cell Reports 18, 1–16.
Alavattam KG *, Mitzelfelt KA *, Bonora G, Fields PA, Yang X, Chiu HS, Pabon L, Bertero A, Palpant NJ, Noble WS @, Murry CE @ (2022). Dynamic chromatin organization and regulatory interactions in human endothelial cell differentiation. Stem Cell Reports 18, 1-16
Gogolou A, Souilhol C, Granata I, Wymeersch FJ, Manipur I, Wind M, Frith TJR, Guarini M, Bertero A, Bock C, Halbritter F, Takasato M, Guarracino MR, Tsakiridis A @ (2021). Early anteroposterior regionalisation of human neural crest is shaped by a pro-mesodermal factor. eLife 11, e7426.
Fenix AM *, Miyaoka Y *, Bertero A, Blue SM, Spindler MJ, Tan KKB, Perez-Bermejo JA, Chan AH, … [11 authors], Murry CE @, Conklin BR @, and Salomonis N @ (2021). Gain-of-function cardiomyopathic mutations in RBM20 rewire splicing regulation and re-distribute ribonucleoprotein granules within processing bodies. Nature Communications 12, 6324.
Nakamura K, Neidig LE, Yang X, Weber GJ, El-Nachef D, Tsuchida H, Dupras S, Kalucki FA, Jayabalu A, Futakuchi-Tsuchida A, Nakamura DS, Marchianò S, Bertero A., … [10 authors], Murry CE @ (2021). Pharmacologic therapy for engraftment arrhythmia induced by transplantation of human cardiomyocytes. Stem Cell Reports 16, P2473-87
Marchiano S, Hsiang T-Y, Khanna A, Higashi T, Whitmore LS, Bargehr J, Davaapil H, Chang J, Smith E, Ong LP, Colzani M, Reinecke H, Yang X, Pabon L, Sinha S, Sniadecki NJ, Bertero A, Gale Jr M @, Murry CE @ (2021). SARS-CoV-2 infects human pluripotent stem cell-derived cardiomyocytes, impairing electrical and mechanical function. Stem Cell Reports 16, 478-492
Marchiano S, Nakamura K, Reinecke H, Neidig L, Lai M, Kadota S, Perbellini F, Yang X, ... [15 authors], Kattman S, Thies RS, Sniadecki N, MacLellan WR, Bertero A #, Murry CE #@ (2023). Gene editing to prevent ventricular arrhythmias associated with cardiomyocyte cell therapy. Cell Stem Cell 30, 396-414
Ong LP *@, Bargehr J *, Knight-Schrijver VR, Lee J, Colzani M, Bayraktar S, Bernard WG, Marchiano S, Bertero A, Murry CE, Gambardella L #, Sinha S #@ (2023). Epicardially secreted fibronectin drives cardiomyocyte maturation in 3D-engineered heart tissues. Stem Cell Reports 18, 1–16.
Alavattam KG *, Mitzelfelt KA *, Bonora G, Fields PA, Yang X, Chiu HS, Pabon L, Bertero A, Palpant NJ, Noble WS @, Murry CE @ (2022). Dynamic chromatin organization and regulatory interactions in human endothelial cell differentiation. Stem Cell Reports 18, 1-16
Gogolou A, Souilhol C, Granata I, Wymeersch FJ, Manipur I, Wind M, Frith TJR, Guarini M, Bertero A, Bock C, Halbritter F, Takasato M, Guarracino MR, Tsakiridis A @ (2021). Early anteroposterior regionalisation of human neural crest is shaped by a pro-mesodermal factor. eLife 11, e7426.
Fenix AM *, Miyaoka Y *, Bertero A, Blue SM, Spindler MJ, Tan KKB, Perez-Bermejo JA, Chan AH, … [11 authors], Murry CE @, Conklin BR @, and Salomonis N @ (2021). Gain-of-function cardiomyopathic mutations in RBM20 rewire splicing regulation and re-distribute ribonucleoprotein granules within processing bodies. Nature Communications 12, 6324.
Nakamura K, Neidig LE, Yang X, Weber GJ, El-Nachef D, Tsuchida H, Dupras S, Kalucki FA, Jayabalu A, Futakuchi-Tsuchida A, Nakamura DS, Marchianò S, Bertero A., … [10 authors], Murry CE @ (2021). Pharmacologic therapy for engraftment arrhythmia induced by transplantation of human cardiomyocytes. Stem Cell Reports 16, P2473-87
Marchiano S, Hsiang T-Y, Khanna A, Higashi T, Whitmore LS, Bargehr J, Davaapil H, Chang J, Smith E, Ong LP, Colzani M, Reinecke H, Yang X, Pabon L, Sinha S, Sniadecki NJ, Bertero A, Gale Jr M @, Murry CE @ (2021). SARS-CoV-2 infects human pluripotent stem cell-derived cardiomyocytes, impairing electrical and mechanical function. Stem Cell Reports 16, 478-492
Post-doc (Murry Lab)
Bertero A, Fields PA, Smith AS, Leonard A, Beussman K, Sniadecki NJ, Kim D-H, Tse H-F, Pabon L, Shendure J, Noble WS, Murry CE @ (2019). Chromatin compartment dynamics in a haploinsufficient model of cardiac laminopathy. Journal of Cell Biology 218, 2919-44
Bargher J, Ong L, Colzani M, Davaapil H, Hofsteen P, Bhandari S, Gambardella L, Le Novère N, Iyer D, Sampaziotis F, Weinberger F, Bertero A, Leonard A, Bernard WG, Martinson A, Figg N, Reigner M, Bennett M, Murry CE #@, Sinha S #@ (2019). Human embryonic stem cell-derived epicardial cells augment cardiomyocyte-driven heart regeneration. Nature Biotechnology 37, 895-906
Salvarani N *, Crasto S *, Miragoli M , Bertero A, Paulis M, Kunderfranco P, Serio S, Forni A, Lucarelli C, Dal Ferro M, Larcher V, Sinagra G, Vezzoni P, Murry CE, Faggian G, Condorelli G @, Di Pasquale E @. (2019). The K219T-Lamin mutation induces conduction defects through epigenetic inhibition of SCN5A in human cardiac laminopathy. Nature Communications 10, 2267
Bertero A *, Fields PA *, Ramani V, Bonora G, Yardimci GG, Reinecke H, Pabon L, Noble WS, Shendure J, Murry CE @ (2019). Dynamics of genome reorganization during human cardiogenesis reveal an RBM20-dependent splicing factory. Nature Communications 10, 1538
Leonard A, Bertero A, Powers JD, Beussman KM, Bhandari S, Regnier M, Murry CE @, and Sniadecki NJ @ (2018). Afterload promotes maturation of human induced pluripotent stem cell derived cardiomyocytes in engineered heart tissues. Journal of Molecular and Cellular Cardiology 118, 147–58
Bertero A, Fields PA, Smith AS, Leonard A, Beussman K, Sniadecki NJ, Kim D-H, Tse H-F, Pabon L, Shendure J, Noble WS, Murry CE @ (2019). Chromatin compartment dynamics in a haploinsufficient model of cardiac laminopathy. Journal of Cell Biology 218, 2919-44
Bargher J, Ong L, Colzani M, Davaapil H, Hofsteen P, Bhandari S, Gambardella L, Le Novère N, Iyer D, Sampaziotis F, Weinberger F, Bertero A, Leonard A, Bernard WG, Martinson A, Figg N, Reigner M, Bennett M, Murry CE #@, Sinha S #@ (2019). Human embryonic stem cell-derived epicardial cells augment cardiomyocyte-driven heart regeneration. Nature Biotechnology 37, 895-906
Salvarani N *, Crasto S *, Miragoli M , Bertero A, Paulis M, Kunderfranco P, Serio S, Forni A, Lucarelli C, Dal Ferro M, Larcher V, Sinagra G, Vezzoni P, Murry CE, Faggian G, Condorelli G @, Di Pasquale E @. (2019). The K219T-Lamin mutation induces conduction defects through epigenetic inhibition of SCN5A in human cardiac laminopathy. Nature Communications 10, 2267
Bertero A *, Fields PA *, Ramani V, Bonora G, Yardimci GG, Reinecke H, Pabon L, Noble WS, Shendure J, Murry CE @ (2019). Dynamics of genome reorganization during human cardiogenesis reveal an RBM20-dependent splicing factory. Nature Communications 10, 1538
Leonard A, Bertero A, Powers JD, Beussman KM, Bhandari S, Regnier M, Murry CE @, and Sniadecki NJ @ (2018). Afterload promotes maturation of human induced pluripotent stem cell derived cardiomyocytes in engineered heart tissues. Journal of Molecular and Cellular Cardiology 118, 147–58
PhD (Vallier lab)
Bertero A *, Brown S *, Madrigal P, Osnato A, Ortmann D, Yiangou L, Kadiwala J, Hubner NC, de Los Mozos IR, Sadee C, Lenaerts A-S, Nakanoh S, Grandy R, Farnell E, Ule J, Stunnenberg HG, Mendjan S, Vallier L @ (2018). The SMAD2/3 interactome reveals that TGFβ controls m6A mRNA methylation in pluripotency. Nature 555, 256–9
Fogarty NME, McCarthy A, Snijders KE, Powell BE, Kubikova N, Blakeley P, Lea R, Elder K, Wamaitha SE, Kim D, Maciulyte V, Kleinjung J, Kim J-S, Wells D, Vallier L, Bertero A, Turner JMA, Niakan KK @ (2017). Genome editing reveals a role for OCT4 in human embryogenesis. Nature 550, 67–73
Sampaziotis F, Justin AW, Tysoe OC, Sawiak S, Godfrey EM, Upponi SS, Gieseck RL, De Brito MC, Berntsen NL, Gómez-Vázquez MJ, Ortmann D, Yiangou L, Ross A, Bargehr J, Bertero A, ... [26 authors], Saeb-Parsy K #, Vallier L #@ (2017). Reconstruction of the mouse extrahepatic biliary tree using primary human extrahepatic cholangiocyte organoids. Nature Medicine 23, 954–63
Pawlowski M *@, Ortmann D *, Bertero A *, Tavares JM, Pedersen RA, Vallier L, Kotter MRN @ (2017). Inducible and Deterministic Forward Programming of Human Pluripotent Stem Cells into Neurons, Skeletal Myocytes, and Oligodendrocytes. Stem Cell Reports 8, 803–12
Sampaziotis F, Cardoso de Brito M, Geti I, Bertero A, Hannan NRF @, and Vallier L @ (2017). Directed differentiation of human induced pluripotent stem cells into functional cholangiocyte-like cells. Nature Protocols 12, 814–27
Bertero A *@, Pawlowski M *, Ortmann D *, Snijders K, Yiangou L, Cardoso de Brito M, Brown S, Bernard WG, Cooper JD, Giacomelli E, Gambardella , Hannan NRF, Iyer D, Sampaziotis F, Serrano F, Zonneveld MCF, Sinha S, Kotter MRN, Vallier L @ (2016). Optimized inducible shRNA and CRISPR/Cas9
platforms for in vitro studies of human development using hPSCs. Development 143, 4405–18
Pauklin S @, Madrigal P, Bertero A, and Vallier L @ (2016). Initiation of stem cell differentiation involves cell cycle-dependent regulation of developmental genes by Cyclin D. Genes & Development 30, 421–33
Sampaziotis F, De Brito MC, Madrigal P, Bertero A, Saeb-Parsy K, Soares FAC, Schrumpf E, Melum E, Karlsen TH, Bradley JA, Gelson WTH, Davies S, Baker A, Kaser A, Alexander GJ, Hannan NRF.#, Vallier L #@ (2015). Cholangiocytes derived from human induced pluripotent stem cells for disease
modeling and drug validation. Nature Biotechnology 33, 845-52
Bertero A, Madrigal P, Galli A, Hubner NC, Moreno I, Burks D, Brown S, Pedersen RA, Gaffney D, Mendjan S#, Pauklin S #, Vallier L #@ (2015). Activin/Nodal signaling and NANOG orchestrate human embryonic stem cell fate decisions by controlling the H3K4me3 chromatin mark. Genes & Development 29, 702–17
Bertero A *, Brown S *, Madrigal P, Osnato A, Ortmann D, Yiangou L, Kadiwala J, Hubner NC, de Los Mozos IR, Sadee C, Lenaerts A-S, Nakanoh S, Grandy R, Farnell E, Ule J, Stunnenberg HG, Mendjan S, Vallier L @ (2018). The SMAD2/3 interactome reveals that TGFβ controls m6A mRNA methylation in pluripotency. Nature 555, 256–9
Fogarty NME, McCarthy A, Snijders KE, Powell BE, Kubikova N, Blakeley P, Lea R, Elder K, Wamaitha SE, Kim D, Maciulyte V, Kleinjung J, Kim J-S, Wells D, Vallier L, Bertero A, Turner JMA, Niakan KK @ (2017). Genome editing reveals a role for OCT4 in human embryogenesis. Nature 550, 67–73
Sampaziotis F, Justin AW, Tysoe OC, Sawiak S, Godfrey EM, Upponi SS, Gieseck RL, De Brito MC, Berntsen NL, Gómez-Vázquez MJ, Ortmann D, Yiangou L, Ross A, Bargehr J, Bertero A, ... [26 authors], Saeb-Parsy K #, Vallier L #@ (2017). Reconstruction of the mouse extrahepatic biliary tree using primary human extrahepatic cholangiocyte organoids. Nature Medicine 23, 954–63
Pawlowski M *@, Ortmann D *, Bertero A *, Tavares JM, Pedersen RA, Vallier L, Kotter MRN @ (2017). Inducible and Deterministic Forward Programming of Human Pluripotent Stem Cells into Neurons, Skeletal Myocytes, and Oligodendrocytes. Stem Cell Reports 8, 803–12
Sampaziotis F, Cardoso de Brito M, Geti I, Bertero A, Hannan NRF @, and Vallier L @ (2017). Directed differentiation of human induced pluripotent stem cells into functional cholangiocyte-like cells. Nature Protocols 12, 814–27
Bertero A *@, Pawlowski M *, Ortmann D *, Snijders K, Yiangou L, Cardoso de Brito M, Brown S, Bernard WG, Cooper JD, Giacomelli E, Gambardella , Hannan NRF, Iyer D, Sampaziotis F, Serrano F, Zonneveld MCF, Sinha S, Kotter MRN, Vallier L @ (2016). Optimized inducible shRNA and CRISPR/Cas9
platforms for in vitro studies of human development using hPSCs. Development 143, 4405–18
Pauklin S @, Madrigal P, Bertero A, and Vallier L @ (2016). Initiation of stem cell differentiation involves cell cycle-dependent regulation of developmental genes by Cyclin D. Genes & Development 30, 421–33
Sampaziotis F, De Brito MC, Madrigal P, Bertero A, Saeb-Parsy K, Soares FAC, Schrumpf E, Melum E, Karlsen TH, Bradley JA, Gelson WTH, Davies S, Baker A, Kaser A, Alexander GJ, Hannan NRF.#, Vallier L #@ (2015). Cholangiocytes derived from human induced pluripotent stem cells for disease
modeling and drug validation. Nature Biotechnology 33, 845-52
Bertero A, Madrigal P, Galli A, Hubner NC, Moreno I, Burks D, Brown S, Pedersen RA, Gaffney D, Mendjan S#, Pauklin S #, Vallier L #@ (2015). Activin/Nodal signaling and NANOG orchestrate human embryonic stem cell fate decisions by controlling the H3K4me3 chromatin mark. Genes & Development 29, 702–17
Pre-doc (Tarone, Brancaccio & Trono labs)
Sbroggiò M, Bertero A, Velasco S, Fusella F, De Blasio E, Bahou WF, Silengo L, Turco E, Brancaccio M @, Tarone G @ (2011). ERK1/2 activation in heart is controlled by melusin, focal adhesion kinase and the scaffold protein IQGAP1. Journal of Cell Science 124, 3515–24
Sbroggiò M, Carnevale D, Bertero A, Cifelli G, De Blasio E, Mascio G, Hirsch E, Bahou WF, Turco E, Silengo L, Brancaccio M, Lembo G, Tarone G @ (2011). IQGAP1 regulates ERK1/2 and AKT signalling in the heart and sustains functional remodelling upon pressure overload. Cardiovascular Research 91, 461–70
Bulliard Y, Narvaiza I, Bertero A, Peddi S, Röhrig UF, Ortiz M, Zoete V, Castro-Díaz N, Turelli P, Telenti A, Michielin O, Weitzman MD, Trono D @ (2011). Structure-function analyses point to a polynucleotide-accommodating groove essential for APOBEC3A restriction activities. Journal of Virology 85, 1765-76
Sbroggiò M, Bertero A, Velasco S, Fusella F, De Blasio E, Bahou WF, Silengo L, Turco E, Brancaccio M @, Tarone G @ (2011). ERK1/2 activation in heart is controlled by melusin, focal adhesion kinase and the scaffold protein IQGAP1. Journal of Cell Science 124, 3515–24
Sbroggiò M, Carnevale D, Bertero A, Cifelli G, De Blasio E, Mascio G, Hirsch E, Bahou WF, Turco E, Silengo L, Brancaccio M, Lembo G, Tarone G @ (2011). IQGAP1 regulates ERK1/2 and AKT signalling in the heart and sustains functional remodelling upon pressure overload. Cardiovascular Research 91, 461–70
Bulliard Y, Narvaiza I, Bertero A, Peddi S, Röhrig UF, Ortiz M, Zoete V, Castro-Díaz N, Turelli P, Telenti A, Michielin O, Weitzman MD, Trono D @ (2011). Structure-function analyses point to a polynucleotide-accommodating groove essential for APOBEC3A restriction activities. Journal of Virology 85, 1765-76