Primary Research
*: co-first authors; #: corresponding/senior author(s); bold text: PI/lab authors; underlined text: primary publications from the PI/lab
Privately archived full texts are provided by the author for personal use only; use the links to the publishers for all other pourposes
*: co-first authors; #: corresponding/senior author(s); bold text: PI/lab authors; underlined text: primary publications from the PI/lab
Privately archived full texts are provided by the author for personal use only; use the links to the publishers for all other pourposes
Faculty
Marchiano S., Nakamura K., Reinecke H., Neidig L., Lai M., Kadota S., Perbellini F., Yang X., ... [15 authors], Kattman S., Thies R.S., Sniadecki N., MacLellan W.R., Bertero A. #, Murry C.E. # (2023). Gene editing to prevent ventricular arrhythmias associated with cardiomyocyte cell therapy. Cell Stem Cell 30, 396-414
Ong L.P.*, Bargehr J.*, Knight-Schrijver V.R., Lee J., Colzani M., Bayraktar S., Bernard W.G., Marchiano S., Bertero A., Murry C.E., Gambardella L.#, Sinha S # (2023). Epicardially secreted fibronectin drives cardiomyocyte maturation in 3D-engineered heart tissues. Stem Cell Reports 18, 1–16.
Alavattam K.G.*, Mitzelfelt K.A.*, Bonora G., Fields P.A., Yang X., Chiu H.S., Pabon L., Bertero A., Palpant N.J., Noble W.S.#, and Murry C.E#. (2022). Dynamic chromatin organization and regulatory interactions in human endothelial cell differentiation. Stem Cell Reports 18, 1-16
Gogolou A., Souilhol C., Granata I., Wymeersch F.J., Manipur I., Wind M., Frith T.J.R., Guarini M., Bertero A., Bock C., Halbritter F., Takasato M., Guarracino M.R., and Tsakiridis A. # (2021). Early anteroposterior regionalisation of human neural crest is shaped by a pro-mesodermal factor. eLife 11, e7426.
Fenix, A.M. *, Miyaoka, Y. *, Bertero, A., Blue, S.M., Spindler, M.J., Tan, K.K.B., Perez-bermejo, J.A., Chan, A.H., … [11 authors], Murry, C.E. #, Conklin, B.R. #, and Salomonis, N#. (2021). Gain-of-function cardiomyopathic mutations in RBM20 rewire splicing regulation and re-distribute ribonucleoprotein granules within processing bodies. Nature Communications 12, 6324.
Nakamura K., Neidig L.E., Yang X., Weber G.J., El-Nachef D., Tsuchida H., Dupras S., Kalucki F.A., Jayabalu A., Futakuchi-Tsuchida A., Nakamura D.S., Marchianò S., Bertero A., … [10 authors], and Murry C.E.# (2021). Pharmacologic therapy for engraftment arrhythmia induced by transplantation of human cardiomyocytes. Stem Cell Reports 16, P2473-87
Marchiano S., Hsiang T.-Y., Khanna A., Higashi T., Whitmore L.S., Bargehr J., Davaapil H., Chang J., Smith E., Ong L.P., Colzani M., Reinecke H., Yang X., Pabon L., Sinha S., Sniadecki N.J., Bertero A., Gale Jr M.#, and Murry C.E.# (2021). SARS-CoV-2 infects human pluripotent stem cell-derived cardiomyocytes, impairing electrical and mechanical function. Stem Cell Reports 16, 478-492
Marchiano S., Nakamura K., Reinecke H., Neidig L., Lai M., Kadota S., Perbellini F., Yang X., ... [15 authors], Kattman S., Thies R.S., Sniadecki N., MacLellan W.R., Bertero A. #, Murry C.E. # (2023). Gene editing to prevent ventricular arrhythmias associated with cardiomyocyte cell therapy. Cell Stem Cell 30, 396-414
Ong L.P.*, Bargehr J.*, Knight-Schrijver V.R., Lee J., Colzani M., Bayraktar S., Bernard W.G., Marchiano S., Bertero A., Murry C.E., Gambardella L.#, Sinha S # (2023). Epicardially secreted fibronectin drives cardiomyocyte maturation in 3D-engineered heart tissues. Stem Cell Reports 18, 1–16.
Alavattam K.G.*, Mitzelfelt K.A.*, Bonora G., Fields P.A., Yang X., Chiu H.S., Pabon L., Bertero A., Palpant N.J., Noble W.S.#, and Murry C.E#. (2022). Dynamic chromatin organization and regulatory interactions in human endothelial cell differentiation. Stem Cell Reports 18, 1-16
Gogolou A., Souilhol C., Granata I., Wymeersch F.J., Manipur I., Wind M., Frith T.J.R., Guarini M., Bertero A., Bock C., Halbritter F., Takasato M., Guarracino M.R., and Tsakiridis A. # (2021). Early anteroposterior regionalisation of human neural crest is shaped by a pro-mesodermal factor. eLife 11, e7426.
Fenix, A.M. *, Miyaoka, Y. *, Bertero, A., Blue, S.M., Spindler, M.J., Tan, K.K.B., Perez-bermejo, J.A., Chan, A.H., … [11 authors], Murry, C.E. #, Conklin, B.R. #, and Salomonis, N#. (2021). Gain-of-function cardiomyopathic mutations in RBM20 rewire splicing regulation and re-distribute ribonucleoprotein granules within processing bodies. Nature Communications 12, 6324.
Nakamura K., Neidig L.E., Yang X., Weber G.J., El-Nachef D., Tsuchida H., Dupras S., Kalucki F.A., Jayabalu A., Futakuchi-Tsuchida A., Nakamura D.S., Marchianò S., Bertero A., … [10 authors], and Murry C.E.# (2021). Pharmacologic therapy for engraftment arrhythmia induced by transplantation of human cardiomyocytes. Stem Cell Reports 16, P2473-87
Marchiano S., Hsiang T.-Y., Khanna A., Higashi T., Whitmore L.S., Bargehr J., Davaapil H., Chang J., Smith E., Ong L.P., Colzani M., Reinecke H., Yang X., Pabon L., Sinha S., Sniadecki N.J., Bertero A., Gale Jr M.#, and Murry C.E.# (2021). SARS-CoV-2 infects human pluripotent stem cell-derived cardiomyocytes, impairing electrical and mechanical function. Stem Cell Reports 16, 478-492
Post-doc (Murry Lab)
Bertero A., Fields P.A., Smith A.S., Leonard A., Beussman K., Sniadecki N.J., Kim D.-H., Tse H.-F., Pabon L., Shendure J., Noble W.S., and Murry C.E.# (2019). Chromatin compartment dynamics in a haploinsufficient model of cardiac laminopathy. Journal of Cell Biology 218, 2919-44
Bargher J., Ong L., Colzani M., Davaapil H., Hofsteen P., Bhandari S., Gambardella L., Le Novère N., Iyer D., Sampaziotis F., Weinberger F., Bertero A., Leonard A., Bernard W.G., Martinson A., Figg N., Reigner M., Bennett M., Murry C.E#., Sinha S#. (2019). Human embryonic stem cell-derived epicardial cells augment cardiomyocyte-driven heart regeneration. Nature Biotechnology 37, 895-906
Salvarani N.*, Crasto S.*, Miragoli M., Bertero A., Paulis M., Kunderfranco P., Serio S., Forni A., Lucarelli C., Dal Ferro M., Larcher V., Sinagra G., Vezzoni P., Murry C.E., Faggian G., Condorelli G.#, and Di Pasquale E#. (2019). The K219T-Lamin mutation induces conduction defects through epigenetic inhibition of SCN5A in human cardiac laminopathy. Nature Communications 10, 2267
Bertero A*., Fields P.A*., Ramani V., Bonora G., Yardimci G.G., Reinecke H., Pabon L., Noble W.S., Shendure J., and Murry C.E.# (2019). Dynamics of genome reorganization during human cardiogenesis reveal an RBM20-dependent splicing factory. Nature Communications 10, 1538
Leonard A., Bertero A., Powers J.D., Beussman K.M., Bhandari S., Regnier M., Murry C.E.#, and Sniadecki N.J.# (2018). Afterload promotes maturation of human induced pluripotent stem cell derived cardiomyocytes in engineered heart tissues. Journal of Molecular and Cellular Cardiology 118, 147–58
Bertero A., Fields P.A., Smith A.S., Leonard A., Beussman K., Sniadecki N.J., Kim D.-H., Tse H.-F., Pabon L., Shendure J., Noble W.S., and Murry C.E.# (2019). Chromatin compartment dynamics in a haploinsufficient model of cardiac laminopathy. Journal of Cell Biology 218, 2919-44
Bargher J., Ong L., Colzani M., Davaapil H., Hofsteen P., Bhandari S., Gambardella L., Le Novère N., Iyer D., Sampaziotis F., Weinberger F., Bertero A., Leonard A., Bernard W.G., Martinson A., Figg N., Reigner M., Bennett M., Murry C.E#., Sinha S#. (2019). Human embryonic stem cell-derived epicardial cells augment cardiomyocyte-driven heart regeneration. Nature Biotechnology 37, 895-906
Salvarani N.*, Crasto S.*, Miragoli M., Bertero A., Paulis M., Kunderfranco P., Serio S., Forni A., Lucarelli C., Dal Ferro M., Larcher V., Sinagra G., Vezzoni P., Murry C.E., Faggian G., Condorelli G.#, and Di Pasquale E#. (2019). The K219T-Lamin mutation induces conduction defects through epigenetic inhibition of SCN5A in human cardiac laminopathy. Nature Communications 10, 2267
Bertero A*., Fields P.A*., Ramani V., Bonora G., Yardimci G.G., Reinecke H., Pabon L., Noble W.S., Shendure J., and Murry C.E.# (2019). Dynamics of genome reorganization during human cardiogenesis reveal an RBM20-dependent splicing factory. Nature Communications 10, 1538
Leonard A., Bertero A., Powers J.D., Beussman K.M., Bhandari S., Regnier M., Murry C.E.#, and Sniadecki N.J.# (2018). Afterload promotes maturation of human induced pluripotent stem cell derived cardiomyocytes in engineered heart tissues. Journal of Molecular and Cellular Cardiology 118, 147–58
PhD (Vallier lab)
Bertero A*., Brown S*., Madrigal P., Osnato A., Ortmann D., Yiangou L., Kadiwala J., Hubner N.C., de Los Mozos I.R., Sadee C., Lenaerts A.-S., Nakanoh S., Grandy R., Farnell E., Ule J., Stunnenberg H.G., Mendjan S., and Vallier L.# (2018). The SMAD2/3 interactome reveals that TGFβ controls m6A mRNA methylation in pluripotency. Nature 555, 256–9
Fogarty N.M.E., McCarthy A., Snijders K.E., Powell B.E., Kubikova N., Blakeley P., Lea R., Elder K., Wamaitha S.E., Kim D., Maciulyte V., Kleinjung J., Kim J.-S., Wells D., Vallier L., Bertero A., Turner J.M.A., and Niakan K.K.# (2017). Genome editing reveals a role for OCT4 in human embryogenesis. Nature 550, 67–73
Sampaziotis F., Justin A.W., Tysoe O.C., Sawiak S., Godfrey E.M., Upponi S.S., Gieseck R.L., De Brito M.C., Berntsen N.L., Gómez-Vázquez M.J., Ortmann D., Yiangou L., Ross A., Bargehr J., Bertero A., ... [26 authors], Saeb-Parsy K.#, and Vallier L.# (2017). Reconstruction of the mouse extrahepatic biliary tree using primary human
extrahepatic cholangiocyte organoids. Nature Medicine 23, 954–63
Pawlowski M.*,#, Ortmann D.*, Bertero A.*, Tavares J.M., Pedersen R.A., Vallier L., and Kotter M.R.N.# (2017). Inducible and Deterministic Forward Programming of Human Pluripotent Stem Cells into Neurons, Skeletal Myocytes, and Oligodendrocytes. Stem Cell Reports 8, 803–12
Bertero A.*,#, Pawlowski M.*, Ortmann D.*, Snijders K., Yiangou L., Cardoso de Brito M., Brown S., Bernard W.G., Cooper J.D, Giacomelli E., Gambardella L., Hannan N.R.F., Iyer D., Sampaziotis F., Serrano F., Zonneveld M.C.F., Sinha S., Kotter M., and Vallier L.# (2016). Optimized inducible shRNA and CRISPR/Cas9
platforms for in vitro studies of human development using hPSCs. Development 143, 4405–18
Pauklin S.#, Madrigal P., Bertero A., and Vallier L#. (2016). Initiation of stem cell differentiation involves cell cycle-dependent regulation of developmental genes by Cyclin D. Genes & Development 30, 421–33
Sampaziotis F., De Brito M.C., Madrigal P., Bertero A., Saeb-Parsy K., Soares F.A.C., Schrumpf E., Melum E., Karlsen T.H., Bradley J.A., Gelson W.T.H., Davies S., Baker A., Kaser A., Alexander G.J., Hannan N.R.F.#, and Vallier L.# (2015). Cholangiocytes derived from human induced pluripotent stem cells for disease
modeling and drug validation. Nature Biotechnology 33, 845-52
Bertero A., Madrigal P., Galli A., Hubner N.C., Moreno I., Burks D., Brown S., Pedersen R.A., Gaffney D., Mendjan S.#, Pauklin S.#, and Vallier L.# (2015). Activin/Nodal signaling and NANOG orchestrate human embryonic stem cell fate decisions by controlling the H3K4me3 chromatin mark. Genes & Development 29, 702–17
Bertero A*., Brown S*., Madrigal P., Osnato A., Ortmann D., Yiangou L., Kadiwala J., Hubner N.C., de Los Mozos I.R., Sadee C., Lenaerts A.-S., Nakanoh S., Grandy R., Farnell E., Ule J., Stunnenberg H.G., Mendjan S., and Vallier L.# (2018). The SMAD2/3 interactome reveals that TGFβ controls m6A mRNA methylation in pluripotency. Nature 555, 256–9
Fogarty N.M.E., McCarthy A., Snijders K.E., Powell B.E., Kubikova N., Blakeley P., Lea R., Elder K., Wamaitha S.E., Kim D., Maciulyte V., Kleinjung J., Kim J.-S., Wells D., Vallier L., Bertero A., Turner J.M.A., and Niakan K.K.# (2017). Genome editing reveals a role for OCT4 in human embryogenesis. Nature 550, 67–73
Sampaziotis F., Justin A.W., Tysoe O.C., Sawiak S., Godfrey E.M., Upponi S.S., Gieseck R.L., De Brito M.C., Berntsen N.L., Gómez-Vázquez M.J., Ortmann D., Yiangou L., Ross A., Bargehr J., Bertero A., ... [26 authors], Saeb-Parsy K.#, and Vallier L.# (2017). Reconstruction of the mouse extrahepatic biliary tree using primary human
extrahepatic cholangiocyte organoids. Nature Medicine 23, 954–63
Pawlowski M.*,#, Ortmann D.*, Bertero A.*, Tavares J.M., Pedersen R.A., Vallier L., and Kotter M.R.N.# (2017). Inducible and Deterministic Forward Programming of Human Pluripotent Stem Cells into Neurons, Skeletal Myocytes, and Oligodendrocytes. Stem Cell Reports 8, 803–12
Bertero A.*,#, Pawlowski M.*, Ortmann D.*, Snijders K., Yiangou L., Cardoso de Brito M., Brown S., Bernard W.G., Cooper J.D, Giacomelli E., Gambardella L., Hannan N.R.F., Iyer D., Sampaziotis F., Serrano F., Zonneveld M.C.F., Sinha S., Kotter M., and Vallier L.# (2016). Optimized inducible shRNA and CRISPR/Cas9
platforms for in vitro studies of human development using hPSCs. Development 143, 4405–18
Pauklin S.#, Madrigal P., Bertero A., and Vallier L#. (2016). Initiation of stem cell differentiation involves cell cycle-dependent regulation of developmental genes by Cyclin D. Genes & Development 30, 421–33
Sampaziotis F., De Brito M.C., Madrigal P., Bertero A., Saeb-Parsy K., Soares F.A.C., Schrumpf E., Melum E., Karlsen T.H., Bradley J.A., Gelson W.T.H., Davies S., Baker A., Kaser A., Alexander G.J., Hannan N.R.F.#, and Vallier L.# (2015). Cholangiocytes derived from human induced pluripotent stem cells for disease
modeling and drug validation. Nature Biotechnology 33, 845-52
Bertero A., Madrigal P., Galli A., Hubner N.C., Moreno I., Burks D., Brown S., Pedersen R.A., Gaffney D., Mendjan S.#, Pauklin S.#, and Vallier L.# (2015). Activin/Nodal signaling and NANOG orchestrate human embryonic stem cell fate decisions by controlling the H3K4me3 chromatin mark. Genes & Development 29, 702–17
Pre-doc (Tarone, Brancaccio & Trono labs)
Sbroggiò M., Bertero A., Velasco S., Fusella F., De Blasio E., Bahou W.F., Silengo L., Turco E., Brancaccio M.#, and Tarone G.# (2011). ERK1/2 activation in heart is controlled by melusin, focal adhesion kinase and the scaffold protein IQGAP1. Journal of Cell Science 124, 3515–24
Sbroggiò M., Carnevale D., Bertero A., Cifelli G., De Blasio E., Mascio G., Hirsch E., Bahou W.F., Turco E., Silengo L., Brancaccio M., Lembo G., and Tarone G.# (2011). IQGAP1 regulates ERK1/2 and AKT signalling in the heart and sustains functional remodelling upon pressure overload. Cardiovascular Research 91, 461–70
Bulliard Y., Narvaiza I., Bertero A., Peddi S., Röhrig U.F., Ortiz M., Zoete V., Castro-Díaz N., Turelli P., Telenti A., Michielin O., Weitzman M.D., and Trono D.# (2011). Structure-function analyses point to a polynucleotide-accommodating groove essential for APOBEC3A restriction activities. Journal of Virology 85, 1765-76
Sbroggiò M., Bertero A., Velasco S., Fusella F., De Blasio E., Bahou W.F., Silengo L., Turco E., Brancaccio M.#, and Tarone G.# (2011). ERK1/2 activation in heart is controlled by melusin, focal adhesion kinase and the scaffold protein IQGAP1. Journal of Cell Science 124, 3515–24
Sbroggiò M., Carnevale D., Bertero A., Cifelli G., De Blasio E., Mascio G., Hirsch E., Bahou W.F., Turco E., Silengo L., Brancaccio M., Lembo G., and Tarone G.# (2011). IQGAP1 regulates ERK1/2 and AKT signalling in the heart and sustains functional remodelling upon pressure overload. Cardiovascular Research 91, 461–70
Bulliard Y., Narvaiza I., Bertero A., Peddi S., Röhrig U.F., Ortiz M., Zoete V., Castro-Díaz N., Turelli P., Telenti A., Michielin O., Weitzman M.D., and Trono D.# (2011). Structure-function analyses point to a polynucleotide-accommodating groove essential for APOBEC3A restriction activities. Journal of Virology 85, 1765-76